The effect of curcumin on symptoms and quality of life in patients with irritable bowel syndrome

Abstract Introduction Irritable bowel syndrome (IBS) is the cause of numerous gastroenterological consultations. Due to multifactorial pathogenesis, treatment IBS difficult. Even management with new medications appears unsatisfactory. Recent reports on therapy highlight possible beneficial effect curcumin. The aim study was assess efficacy and safety curcumin in patients. Materials Methods Our non-controlled included 51 patients: 30 (58.8%) women 21 (41.2%) men diagnosed based Roman Criteria IV, 35 patients diarrhea-predominant (IBS-D) variant 16 constipation-predominant (IBS-C) variant. quality life severity symptoms were assessed Symptom Severity Score (IBS-SSS) Quality Life Instrument (IBS-QoL) questionnaires all at: 0, 4, 12-week time points. Results A statistically significantly lower IBS-SSS score found after 4 12 weeks using (p < 0.01), especially category bloating abdominal pain. After curcumin, a reduction mean decreased from 279.7 202.2 points 0.05). There significant increase overall obtained IBS-QoL questionnaire first taking compared baseline visit (41,9 vs. 53,4; p No side effects have been reported associated use. Conclusions In summary, effective reducing clinical improving patients’ life. It also has high profile.